Statins in Periodontal Regeneration - The current Scenario
نویسندگان
چکیده
Statins are the group of lipid lowering drugs commonly used to control cardiovascular and cerebrovascular diseases. Statins have structure similar to 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA)reductase and competitively inhibits HMG-CoA reductase, which is the rate-limiting step in the mevalonate pathway, thereby reducing blood cholesterol levels. Statins have potential anti-inflammatory effect. Statins in systemic and local application enhance osteoblastic differentiation and bone formation by upregulating bone morphogenic proteins and by blocking the intermediate metabolites of the mevalonate pathway. Because of these effects statins can be used in treating periodontal disease and promoting periodontal regeneration. Pubmed and Google Scholar were used to search original research articles and reviews about statins in periodontal therapy. The keywords used were statins, periodontal regeneration, mevalonate pathway, HMG CoA reductase inhibitors. From these searches, a total of 25 publications were selected for this review.
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